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Thursday, August 6, 2020 | History

3 edition of Substrate and hormone interrelationships in human myocardial metabolism found in the catalog.

Substrate and hormone interrelationships in human myocardial metabolism

Mark L. Wahlqvist

Substrate and hormone interrelationships in human myocardial metabolism

by Mark L. Wahlqvist

  • 248 Want to read
  • 23 Currently reading

Published in Uppsala .
Written in English

    Subjects:
  • Myocardium.,
  • Energy metabolism.,
  • Hormones -- Physiological effect.

  • Edition Notes

    Statementby Mark L. Wahlqvist.
    SeriesAbstracts of Uppsala dissertations from the Faculty of Medicine ;, 118, Acta Universitatis Upsaliensis, Acta Universitatis Upsaliensis., 118.
    Classifications
    LC ClassificationsQP113.2 .W35
    The Physical Object
    Pagination45 p.
    Number of Pages45
    ID Numbers
    Open LibraryOL4288779M
    LC Control Number78315838

    Given that AcAc is the only known substrate for acetone that exists in mammalian metabolism (via non-enzymatic decarboxylation), acetone serves as a reporter of AcAc, generated from unoxidized [13 C]AcAc during extract preparation, present only in extracts derived from ketogenic diet-fed myocardial samples (p. The possibility of demonstrating noninvasively with C palmitate and positron emission tomography (PET) changes in myocardial substrate metabolism in normal and diseased human myocardium in response to altered substrate availability in blood and disease-related abnormalities was examined in five normal volunteers and 16 patients with.

    Myocardial energy metabolism shows a balance between ATP production and utilization. Thyroid hormone regulates this balance through multiple processes. Accordingly, thyroid hormone can control the cellular environment by modifying the cellular energy state, which in turn influences processes such as transport and protein synthesis. @article{osti_, title = {Effects of acupuncture on the citrate and glucose metabolism in the liver under various types of stress}, author = {Liao, Y Y and Seto, K and Saito, H and Kawakami, M}, abstractNote = {A study was made of the effect of acupuncture on citrate and glucose metabolism in the liver in terms of incorporation of /sup 14/C-1, 5-citric acid and /sup 14/C-u-glucose in.

    35 Heart Metab. () lopascHuk Metabolic changes in the acutely ischemic heart experimental13,14 and clinical studies This results in an increase in glucose oxidation both during and af-ter ischemia,13,14 which decreases the severity of pH changes during ischemia16 and improves contractile function. Relationship in man between plasma free fatty acids and myocardial metabolism of carbohydrate substrates. Lancet ; II Wahlqvist ML. Substrate and hormone interrelationships in human myocardial metabolism.


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Substrate and hormone interrelationships in human myocardial metabolism by Mark L. Wahlqvist Download PDF EPUB FB2

Abstract. OBJECTIVE—Normal human myocardium switches substrate metabolism preference, adapting to the prevailing plasma substrate levels and hormonal milieu, but in type 1 diabetes, the myocardium relies heavily on fatty acid metabolism for r conditions that affect myocardial glucose use and fatty acid utilization, oxidation, and storage in nondiabetic subjects Cited by:   The regulation of myocardial metabolism is linked to arterial carbon substrate concentration, hormone concentrations, coronary flow, inotropic state, and the nutritional status of the tissue (,).The citric acid cycle is fueled by acetyl-CoA formed from decarboxylation of pyruvate and from β-oxidation of fatty acids ().The reducing equivalents (NADH and FADH 2) that are Cited by:   There is minimal in vivo data in humans evaluating myocardial substrate utilization during increased heart work.

This study was performed to determine the balance of myocardial glucose and lactate metabolism during rest and increased heart work induced by atrial pacing in seven healthy men and women (age, ± years; body mass index, ± kg m −2, maximum oxygen Cited by: Furthermore, since the interrelationships which exist in vivo between MEx of a substrate and (1) arterial concentration of the substrate, (2) hormones and (3) extraction of other substrates are.

myocardial substrate metabolism in HF, and not on the well-documented HF-induced abnormalities in the trans-fer of energy from mitochondrial ATP to systolic and diastolic work. The reader is referred to recent reviews on this topic (98,).

OVERVIEW OF MYOCARDIAL SUBSTRATE METABOLISM To understand myocardial metabolism in HF, it isCited by:   Methods and Results. Myocardial blood flow and oxygen consumption, as well as glucose and fatty acid metabolism, were examined retrospectively by use of positron emission tomography in 24 postmenopausal women receiving estrogen (n = 7), estrogen plus progesterone (n = 8), or no hormone replacement (n = 9) and in 22 age-matched men.

Acta histochem. 61, S. () Department of Histology and Embryology, Faculty of Medicine, Medical Academy, Lublin, Poland (Head: Prof. med. STANISLAW GRZYCKI) Some histochemical observations on the myocardial metabolism.

Myocardial metabolism alterations are associated with myocardial dystrophy and lead to the heart chambers dilatation, decreased contractility, organs perfusion and depended on symptoms. Nowadays heart failure treatment in veterinary medicine includes neurohormonal, circulatory and contractile aspects of this pathological state.

Unfortunately, energy supplying component not. Title:Myocardial Energy Substrate Metabolism in Heart Failure: from Pathways to Therapeutic Targets VOLUME: 21 ISSUE: 25 Author(s):Arata Fukushima, Kenneth Milner, Abhishek Gupta and Gary D. Lopaschuk Affiliation Heritage Medical Research Building University of Alberta Edmonton, Alberta T6G 2S2 Canada.

Keywords:Glucose oxidation, heart failure, metabolic therapy, myocardial fatty acid. Myocardial Metabolism All cellular processes require ATP as a primary energy source. The heart requires ATP for the function of membrane transport systems (e.g., Na + /K + -ATPase) as well as for sarcomere contraction and relaxation, which involve myosin ATPase and ATP-dependent transport of calcium by the sarcoplasmic reticulum.

Animal models and small-scale human studies suggest benefits with the use of agents that shift myocardial substrate use from free fatty acids towards glucose, but larger human studies are needed.

Co-morbid conditions, degree of ischemia, degree of FA oxidative metabolism machinery dysfunction, and plasma substrate levels, also appear to affect myocardial metabolism. Moreover, whether an increase in glucose metabolism is adaptive or maladaptive likely depends upon the demands placed on the heart and other superimposed conditions.

Myocardial metabolism. Muhammad Adnan Amin Cardiology, THI Outline Regulation of metabolic pathways in the heart Carbohydrate metabolism Fatty acid metabolism Ketone body metabolism Interregulation of fatty acid and carbohydrate oxidation Effects of substrate selection on contractile function and efficiency.

Regulation of Metabolic Pathways in the Heart. Preptin is a hormone modulating carboh ydrate metabolism; it is a part of the insulin family (as insulin, insulin-like gro w th factor-1, pr oinsulin-like factor-2, relaxin-2).

The regulation of myocardial metabolism is linked to substrate availability, coronary flow, inotropic state, and hormonal regulation. the healthy adult human heart at rest is able to adopt substrate utilisation accordingly to myocardial metabolism is shifted towards a preferential utilization of.

thyroid hormone regulates energy metabolism through an integrated system composed of multiple mechanisms. Triiodothyronine (T 3), the active form of this hormone, works principally through binding to nuclear receptors (11, 18, 24, 30).These bind in turn to thyroid hormone response elements and modulate transcription of responsive target genes and drive protein synthesis.

Objectives This study was designed to evaluate myocardial substrate and high-energy phosphate (HEP) metabolism in asymptomatic men with well-controlled, uncomplicated type 2 diabetes with verified absence of cardiac ischemia, and age-matched control subjects, and to assess the association with myocardial function.

Background Metabolic abnormalities, particularly an excessive exposure of the. One key mechanism through which thyroid hormones affect energy metabolism is the transcriptional induction of mitochondrial uncoupling proteins.

As discussed earlier (slide ), uncoupling proteins mediate the conversion of metabolic energy to heat and therefore increase the burn rate of glucose and other energy-rich substrates. Thyroid hormone and afterload. Afterload is the hemodynamic force exerted on the ventricular wall during ejection, corresponding, therefore, to end-systolic wall stress or tension sensu contributes to the determination of ventricular end-systolic volume and modulates myocardial performance significantly (i.e.

it governs the extent and velocity of wall shortening). Results of studies in animal models show that there are sex differences in myocardial substrate metabolism, with female rats exhibiting less myocardial glucose and more fatty acid metabolism.

52, 53 Recently, using PET with 11 C-glucose and 11 C-plamitate, these observations were confirmed in young healthy volunteers. 54 Women exhibited lower. Altered myocardial substrate metabolism and decreased diastolic function in nonischemic human diabetic cardiomyopathy: studies with cardiac positron emission tomography and magnetic resonance imaging.

J Am Coll Cardiol. ; – Crossref Medline Google Scholar; MD(Adelaide) for the thesis 'Arterial wall metabolism and atherogenesis' MD(Uppsala) for the thesis 'Substrate and hormone inter-relationships in human myocardial metabolism'.Cardiac disease is commonly associated with changes in energy substrate metabolism.

Fatty acid and glucose represent the main fuels used by the heart, and characteristic alterations in substrate preference and utilisation occur early in many cardiac disease processes.

Different substrate classes (lipids, carbohydrates) have different metabolic efficiencies, both in terms of energy (ATP) yield.